NSC 12 (CAS: 102586-30-1) , also known as NSC 172285, is an extracellular FGF trap with significant implications in cancer therapy. NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. In vivo, NSC12 was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells. Importantly, there was no systemic toxic effect.
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TGF-beta/Smad
Phospholipase
