TGF-beta/Smad
Histone Methyltransferase
Products > Epigenetics > Epigenetic Reader Domain inhibitor > Molibresib (GSK525762A; GSK-525762A; I-BET762; I-BET 762)
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Product name : Molibresib (GSK525762A; GSK-525762A; I-BET762; I-BET 762)
Product No. : cs-818
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
GSK 525762A (CAS: 1260907-17-2) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM. GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth.
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