TGF-beta/Smad
PD-1/PD-L1
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Product name : ARN-3236 (ARN3236, ARN 3236)
Product No. : 2019111610389
Price : 100mg/$675; 500mg/$1875
CAS : 1613710-01-2
Bulk inquiry : contact sales@cckinase.com for bulk inquiry
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ARN-3236 (CAS: 1613710-01-2) is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 uncoupled the centrosome from the nucleus in interphase, blocked centrosome separation in mitosis, caused prometaphase arrest, and induced apoptotic cell death and tetraploidy.
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