TGF-beta/Smad
Phospholipase
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Product name : SBI-0206965 (SBI0206965, SBI 0206965)
Product No. : cs-1581
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2. BI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.
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