TGF-beta/Smad
PTEN
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Product name : PF-4989216 (PF4989216, PF 4989216)
Product No. : cs-1547
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
PF-4989216 (CAS: 1276553-09-3) is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits PI3Kalpha (Ki=0.6 nM) and mTOR (Ki=1440 nM). PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.
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