TGF-beta/Smad
EZH2
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Product name : THZ1 (THZ-1, THZ 1)
Product No. : cs-1233
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
THZ1 (CAS: 1604810-83-4) is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis.
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