TGF-beta/Smad
Nampt
Products > Metabolic enzyme/Protease > HSP (e.g. HSP90) inhibitor > PF-04929113 (PF04929113, SNX-5422, SNX5422)
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Product name : PF-04929113 (PF04929113, SNX-5422, SNX5422)
Product No. : 2018101241638
Price : 10mg/$125, 100mg/$775, 500mg/$2475
CAS :
Bulk inquiry :
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| Details: |
PF 04929113 (10mg/$125, 100mg/$775, CAS: 908115-27-5, 1173111-67-5) is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
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