TGF-beta/Smad
PTEN
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Product name : Torin1 (Torin-1)
Product No. : cs-1958
Price : 100mg, $475, 500mg/$1275
CAS :
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| Details: |
Torin 1 (CAS: 1222998-36-8) is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K. Torin-1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44.
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