TGF-beta/Smad
MNK
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Product name : LY3009120 (DP-4978; LY-3009120)
Product No. : cs-1616
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
LY3009120 (CAS: 1454682-72-4) is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.
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